Welcome to the Hansel Lab
One of the most intriguing features of our brains is the ability to learn and to adapt. The main goal of our lab is to study the mechanisms underlying the formation of memories. We focus on the cerebellum, which is a brain area involved in motor coordination and learning, and which also plays a role in cognitive functions. Using patch-clamp recordings from cerebellar slice preparations, we examine activity-dependent changes in synaptic strength (synaptic plasticity) as well as changes in membrane excitability (intrinsic plasticity) that may form a cellular basis for information storage and learning. We also study abnormalities in synaptic physiology and in cerebellar function in autism, which often is associated with motor problems.
Lab News:
Ting’s manuscript ‘Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum‘ has been accepted for publication in Nature Communications! Congratulations!
Silas’ manuscript ‘Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human’ has been published in Science! Congratulations!
Christian’s first book, Memory Makes the Brain, has been released by World Scientific in January 2021! (For more details, see Book.)
Opportunities:
If you are interested in our work and like to inquire about open positions in the lab, please send your CV and application to: chansel@bsd.uchicago.edu