Publications

Busch, S.E. and Hansel, C. (2025). Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum. eLife 14: RP105013.

Lin, T.F., Busch, S.E., and Hansel, C. (2024). Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum. Nat. Commun. 15: 4645.

Busch, S.E. and Hansel, C. (2023). Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human. Science 381: 420-427. https://www.science.org/stoken/author-tokens/ST-1338/full

Yang, R., Feng, X., Arias-Cavieres, A., Mitchell, R.M., Polo, A., Hu, K., Zhong, R., Cai, Q., Zhang, R.S., Westneat, N., Portillo, C.A., Nobrega, M.A., Hansel, C., Garcia III, A.J., and Zhang, X. (2023). Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron 111: 1637-1650.

Pham, T. and Hansel, C. (2023). Intrinsic threshold plasticity: cholinergic activation and role in the neuronal recognition of incomplete input patterns. J. Physiol. 601.15: 3221-3239.

Simmons, D.H., Busch, S.E., Titley, H.K., Grasselli, G., Shih, J., Du, X., Wei, C., Gomez, C. M., Piochon, C., and Hansel, C. (2022). Sensory over-responsivity and aberrant plasticity in cerebellar cortex in a mouse model of syndromic autism. Biol. Psychiatry: GOS. 2: 450-459.

Grasselli, G., Boele, H.J., Titley, H.K., Bradford, N., van Beers, L., Jay, L., Beekhof, G.C., Busch, S.E., De Zeeuw, C.I., Schonewille, M., and Hansel, C. (2020). SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor learning-specific memory traces. PLoS Biology 18: e3000596.

Gill, D.F. and Hansel, C. (2020). Muscarinic modulation of SK2-Type K+ channels promotes intrinsic plasticity in L2/3 pyramidal neurons of the mouse primary somatosensory cortex. eNeuro 7: ENEURO.0453-19.2020.

Titley, H.K., Watkins, G.V., Lin, C., Weiss, C., McCarthy, M., Disterhoft, J.F., and Hansel, C. (2020). Intrinsic excitability increase in cerebellar Purkinje cells following eyeblink conditioning in mice. J. Neurosci. 40: 2038-2046.

Titley, H.K., Kislin, M., Simmons, D.H., Wang, S.S., and Hansel, C. (2019). Complex spike clusters and false-positive rejection in a cerebellar supervised learning rule. J. Physiol. 597: 4387-4406.

Titley, H.K., Brunel N., and Hansel, C. (2017). Toward a neurocentric view of learning. Neuron 95: 19-32.

Piochon, C., Titley, H.K., Simmons, D.H., Grasselli, G., Elgersma, Y., and Hansel, C. (2016). Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.  Proc. Natl. Acad. Sci. USA 113: 13221-13226.

Piochon, C., Kano, M., and Hansel, C. (2016). LTD-like molecular pathways in developmental synaptic pruning.  Nature Neurosci. 19: 1299-1310.

Piochon, C., Kloth, A.D., Grasselli, G., Titley, H.K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D.H., Eissa, T., Nakatani, J., Cherskov, A., Miyazaki, T., Watanabe, M., Takumi, T., Kano, M., Wang, S.S.-H., and Hansel, C. (2014). Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nature Commun. 5: 5586.

Ohtsuki, G., Piochon, C., Adelman, J.P. and Hansel, C. (2012): SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells. Neuron 75, 108-120.

Belmeguenai, A, Hosy, E., Bengtsson, F., Pedroarena, C., Piochon, C., Teuling, E., He, Q., Ohtsuki, G., De Jeu, M.T., Elgersma, Y., De Zeeuw, C.I., Jörntell, H., and Hansel, C. (2010): Intrinsic plasticity complements LTP in parallel fiber input gain control in cerebellar Purkinje cells. J. Neurosci. 30, 13630-13643.

Schonewille, M., Belmeguenai, A., Koekkoek, S.K., Houtman, S.H., Boele, H.J., Van Beugen, B.J., Gao, Z., Badura, A., Ohtsuki, G., Amerika, W.E., Hosy, E., Hoebeek, F.E., Elgersma, Y., Hansel, C. and De Zeeuw, C.I. (2010): Purkinje cell-specific knock-out of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron 67, 618-628.

Hansel, C., de Jeu, M., Belmeguenai, A., Houtman, S.H., Buitendijk, G., Andreev, D., De Zeeuw, C.I. and Elgersma, Y. (2006): aCaMKII is essential for cerebellar LTD and motor learning. Neuron 51, 835-843.

Coesmans, M., Weber, J.T., De Zeeuw, C.I. and Hansel, C. (2004): Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control. Neuron 44, 691-700.