Publications

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Busch, S.E. and Hansel, C. (2023). Multiple climbing fiber innervation of mature Purkinje cells with distinct dendritic subfields. bioRxiv, https://doi.org/10.1101/2023.03.27.534425

Yang, R., Feng, X., Arias-Cavieres, A., Mitchell, R.M., Polo, A., Hu, K., Zhong, R., Cai, Q., Zhang, R.S., Westneat, N., Portillo, C.A., Nobrega, M.A., Hansel, C., Garcia III, A.J., and Zhang, X. (in press). Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron.

Simmons, D.H., Busch, S.E., Titley, H.K., Grasselli, G., Shih, J., Du, X., Wei, C., Gomez, C. M., Piochon, C., and Hansel, C. (2022). Sensory over-responsivity and aberrant plasticity in cerebellar cortex in a mouse model of syndromic autism. Biol. Psychiatry: GOS. 2: 450-459.

Grasselli, G., Boele, H.J., Titley, H.K., Bradford, N., van Beers, L., Jay, L., Beekhof, G.C., Busch, S.E., De Zeeuw, C.I., Schonewille, M., and Hansel, C. (2020). SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor learning-specific memory traces. PLoS Biology 18: e3000596.

Gill, D.F. and Hansel, C. (2020). Muscarinic modulation of SK2-Type K+ channels promotes intrinsic plasticity in L2/3 pyramidal neurons of the mouse primary somatosensory cortex. eNeuro 7: ENEURO.0453-19.2020.

Titley, H.K., Watkins, G.V., Lin, C., Weiss, C., McCarthy, M., Disterhoft, J.F., and Hansel, C. (2020). Intrinsic excitability increase in cerebellar Purkinje cells following eyeblink conditioning in mice. J. Neurosci. 40: 2038-2046.


Titley, H.K., Kislin, M., Simmons, D.H., Wang, S.S., and Hansel, C. (2019). Complex spike clusters and false-positive rejection in a cerebellar supervised learning rule. J. Physiol. 597: 4387-4406.

Titley, H.K., Brunel N., and Hansel, C. (2017). Toward a neurocentric view of learning. Neuron 95: 19-32.

Piochon, C., Titley, H.K., Simmons, D.H., Grasselli, G., Elgersma, Y., and Hansel, C. (2016). Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.  Proc. Natl. Acad. Sci. USA 113: 13221-13226.

Piochon, C., Kano, M., and Hansel, C. (2016). LTD-like molecular pathways in developmental synaptic pruning.  Nature Neurosci. 19: 1299-1310.

Grasselli, G., He, Q., Wan, V., Adelman, J.P., Ohtsuki, G., and Hansel, C. (2016). Activity-dependent plasticity of spike pauses in cerebellar Purkinje cells. Cell Reports 14: 2546-2553.

Kloth, A.D., Badura, A., Li, A., Cherskov, A., Connolly S.G., Giovannucci, A., Bangash, M.A., Grasselli, G., Penagarikano, O., Piochon, C., Tsai, P.T., Geschwind, D.H., Hansel, C., Sahin, M., Takumi, T., Worley, P.F., and Wang, S.S.H. (2015). Cerebellar associative sensory learning defects in five mouse autism models. eLife 4: e06085.

Piochon, C., Kloth, A.D., Grasselli, G., Titley, H.K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D.H., Eissa, T., Nakatani, J., Cherskov, A., Miyazaki, T., Watanabe, M., Takumi, T., Kano, M., Wang, S.S.-H., and Hansel, C. (2014). Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nature Commun. 5: 5586.

Rinaldo, L. and Hansel, C. (2013): Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proc. Natl. Acad. Sci. USA 110: 11181-11186.

Ohtsuki, G., Piochon, C., Adelman, J.P. and Hansel, C. (2012): SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells. Neuron 75, 108-120.

Belmeguenai, A, Hosy, E., Bengtsson, F., Pedroarena, C., Piochon, C., Teuling, E., He, Q., Ohtsuki, G., De Jeu, M.T., Elgersma, Y., De Zeeuw, C.I., Jörntell, H., and Hansel, C. (2010): Intrinsic plasticity complements LTP in parallel fiber input gain control in cerebellar Purkinje cells. J. Neurosci. 30, 13630-13643.

Schonewille, M., Belmeguenai, A., Koekkoek, S.K., Houtman, S.H., Boele, H.J., Van Beugen, B.J., Gao, Z., Badura, A., Ohtsuki, G., Amerika, W.E., Hosy, E., Hoebeek, F.E., Elgersma, Y., Hansel, C. and De Zeeuw, C.I. (2010): Purkinje cell-specific knock-out of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron 67, 618-628.

Hansel, C., de Jeu, M., Belmeguenai, A., Houtman, S.H., Buitendijk, G., Andreev, D., De Zeeuw, C.I. and Elgersma, Y. (2006): aCaMKII is essential for cerebellar LTD and motor learning. Neuron 51, 835-843.

Coesmans, M., Weber, J.T., De Zeeuw, C.I. and Hansel, C. (2004): Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control. Neuron 44, 691-700.

Hansel, C., Linden, D.J. and D’Angelo, E. (2001). Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum. Nature Neurosci. 4, 467-475.